PDE9A - phosphodiesterase 9A Gene

Homo sapiens

Also known as HSPDE9A2

Gene ID: 5152 | Gene type: protein coding

About PDE9A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,653,621-42,775,509 (from NCBI)

This gene has 28 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in colon (RPKM 12.5), prostate (RPKM 9.8) and 17 other tissues.

Summary

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PDE9A Products(24)

mRNA	Protein	Name
NM_001001576.2	NP_001001576.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j
XM_011529598.3	XP_011527900.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1
NM_001001584.3	NP_001001584.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001583.2	NP_001001583.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o
NM_001001568.2	NP_001001568.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c
NM_001001573.2	NP_001001573.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001572.2	NP_001001572.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001567.2	NP_001001567.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b
NM_001001569.2	NP_001001569.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d
XM_011529600.3	XP_011527902.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2
NM_001001581.2	NP_001001581.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m
NM_001001575.2	NP_001001575.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i
NM_001001578.2	NP_001001578.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l
NM_001001585.2	NP_001001585.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
XM_017028366.2	XP_016883855.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3
NM_002606.3	NP_002597.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a
NM_001001579.2	NP_001001579.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001571.2	NP_001001571.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f
NM_001001582.2	NP_001001582.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n
NM_001001577.2	NP_001001577.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k
NM_001001570.2	NP_001001570.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e
NM_001315533.2	NP_001302462.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform p
NM_001001574.2	NP_001001574.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h
NM_001001580.2	NP_001001580.1	high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3',5'-cyclic-GMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	9624146	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26871637	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cGMP catabolic process	IDA IDA: Inferred from direct assay	25799991	GOA
involved in cGMP metabolic process	IDA IDA: Inferred from direct assay	9624146	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in sarcolemma	IDA IDA: Inferred from direct assay	25799991	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE9A Protein Structure

PDEase_I

0
100
200
300
400
500
593 a.a.

Protein Preferred Names

Protein Names

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

CGMP-specific 3',5'-cyclic phosphodiesterase type 9

phosphodiesterase PDE9A21

PDE9A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDE9A	O76083	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	PDE9A	O76083	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	PDE9A	O76083	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	PDE9A	O76083	LINC02913	Homo sapiens	Q8NAJ2	Validated Y2H	25416956
Intra	PDE9A	O76083	LINC02913	Homo sapiens	Q8NAJ2	Y2H Array	25416956
Intra	PDE9A	O76083	LINC02913	Homo sapiens	Q8NAJ2	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	PHYHIPL	Homo sapiens	Q96FC7-2	Y2H Array	25416956
Intra	PDE9A	O76083	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	PDE9A	O76083	LAGE3	Homo sapiens	Q14657	Validated Y2H	25416956
Intra	PDE9A	O76083	PDE9A	Homo sapiens	O76083-2	Y2H Array	26871637
Intra	PDE9A	O76083	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	26871637
Intra	PDE9A	O76083	PDE9A	Homo sapiens	O76083-2	Validated Y2H	26871637
Intra	PDE9A	O76083	CRY2	Homo sapiens	Q49AN0	Validated Y2H	25416956
Intra	PDE9A	O76083	CLK1	Homo sapiens	P49759	Y2H Array	25416956
Intra	PDE9A	O76083	UTP23	Homo sapiens	Q9BRU9	Y2H Array	25416956
Intra	PDE9A	O76083	SULT1E1	Homo sapiens	P49888	Y2H Array	25416956
Intra	PDE9A	O76083	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	PDE9A	O76083	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956
Intra	PDE9A	O76083	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	29892012
Intra	PDE9A	O76083	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	PDE9A	O76083	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Pooling	16189514
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Array	31515488
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	26871637
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Array	19060904
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Validated Y2H	26871637
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Array	25416956
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Array	26871637
Intra	PDE9A	O76083	TRIM32	Homo sapiens	Q13049	Y2H Pooling	19060904
Intra	PDE9A	O76083	BAG3	Homo sapiens	O95817	Y2H Array	25416956
Intra	PDE9A	O76083	BAG3	Homo sapiens	O95817	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	BAG3	Homo sapiens	O95817	Validated Y2H	25416956
Intra	PDE9A	O76083	ZFAB	Homo sapiens	Q9Y260	Validated Y2H	25416956
Intra	PDE9A	O76083	ZFAB	Homo sapiens	Q9Y260	Y2H Array	25416956
Intra	PDE9A	O76083	ZFAB	Homo sapiens	Q9Y260	Y2H Prey Pooling	25416956
Intra	PDE9A	O76083	NAA38	Homo sapiens	Q9BRA0	Validated Y2H	25416956
Intra	PDE9A	O76083	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	PDE9A	O76083	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDE9A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75962	PDE9A Protein, Human (sf9, His-GST)	O76083-2 (M1-A533)	≥95%
HY-P75963	PDE9A Protein, Human (His)	O76083-2 (P181-K506)	≥95%

Related Diseases

Diseases

Alias

Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Transient Global Amnesia

Amnesia, Transient Global

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15441	Edelinontrine	Inhibitor	99.85%	Phase 2
HY-112831	Osoresnontrine	Inhibitor	99.88%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12788	PF-04449613	Inhibitor	99.83%	Unkown
HY-104028	BAY 73-6691	Inhibitor	99.84%	Unkown
HY-126137	PDE9-IN-1	Inhibitor	99.70%	Unkown
HY-152106	BAY-7081	Inhibitor	98.00%	Unkown
HY-12788A	(S)-PF-04449613	Inhibitor	99.85%	Unkown
HY-104028B	(S)-BAY 73-6691	Control	99.51%	Unkown
HY-RS10246	PDE9A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10247	Pde9a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10248	Pde9a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDE9A	VGNC	VGNC:75925
Bos taurus	PDE9A	VGNC	VGNC:32688
Rattus norvegicus	PDE9A	RGD	RGD:621035
Mus musculus	PDE9A	MGD	MGI:1277179
Felis catus	PDE9A	VGNC	VGNC:68767
Canis familiaris	PDE9A	VGNC	VGNC:44367
Others	PDE9A	NCBI

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