PDYN Protein, Human (HEK293, His)

The PDYN protein, or prodynorphin, regulates Leu-enkephalins, mimicking opiate drug effects and impacting pain perception and stress responses. Dynorphin peptides, like Dynorphin A(1-13), uniquely regulate the kappa opioid receptor, with A(1-13) being exceptionally potent—700 times stronger than Leu-enkephalin—displaying typical opioid activity. PDYN Protein, Human (HEK293, His) is the recombinant human-derived PDYN protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDYN Protein, Human (HEK293, His) is 234 a.a., with molecular weight of ~35.0 kDa.

The PDYN protein, also known as prodynorphin, is associated with Leu-enkephalins, which compete with and emulate the effects of opiate drugs. These peptides play a pivotal role in various physiological functions, including pain perception and responses to stress. Additionally, dynorphin peptides, such as Dynorphin A(1-13), exhibit differential regulation of the kappa opioid receptor. Notably, Dynorphin A(1-13) demonstrates typical opioid activity and is remarkably more potent, being 700 times stronger than Leu-enkephalin.

Human

HEK293

C-6*His

P01213 (D21-A254)

5173  [NCBI]

DCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA

Approximately 35.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.