PELI2 Protein, Human

PELI2 protein is an E3 ubiquitin ligase that links ubiquitin to substrate proteins. PELI2 Protein, Human is the recombinant human-derived PELI2 protein, expressed by E. coli , with tag free. The total length of PELI2 Protein, Human is 419 a.a., .

PELI2, functioning as an E3 ubiquitin ligase, plays a crucial role in catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It actively participates in the Toll-like receptor (TLR) and interleukin-1 (IL-1) signaling pathways by interacting with the complex containing IRAK kinases and TRAF6. Specifically, PELI2 mediates IL1B-induced 'Lys-63'-linked polyubiquitination of IRAK1, and potentially 'Lys-48'-linked ubiquitination, contributing to the intricate regulation of downstream signaling events. Furthermore, PELI2 is implicated in LPS- and IL1B-induced NF-kappa-B activation, specifically via the MAP3K7-dependent pathway. Notably, PELI2's influence extends to the MAP kinase pathway, ultimately resulting in the activation of ELK1. These findings highlight PELI2 as a multifaceted regulator at the intersection of crucial immune signaling cascades, emphasizing its significance in modulating inflammatory responses and cellular signaling.

Human

E. coli

Tag Free

Q9HAT8 (F2-D420)

/

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.