Pentraxin 2/SAP Protein, Human (HEK293, His)

Pentraxin 2/SAP protein, a member of the pentraxin family, promotes innate immunity by recognizing pathogens and promoting their clearance. This soluble pattern recognition receptor is involved in multiple inflammatory processes, including complement activation, opsonization, and immune response regulation. Pentraxin 2/SAP Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 2/SAP protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Pentraxin 2/SAP Protein, Human (HEK293, His) is 204 a.a., with molecular weight of ~30.0 kDa.

CLIC2/XAP121 protein exhibits the capability to insert into membranes, forming chloride ion channels whose activity is pH-dependent. The process of membrane insertion appears to be regulated by redox conditions, occurring predominantly under oxidizing conditions. Notably, CLIC2/XAP121 plays a regulatory role in modulating RYR2 activity, ultimately inhibiting calcium influx. This protein functions as a monomer and engages in interactions with TRAPPC2 and RYR2, suggesting a potential role in intricate cellular processes.

Human

HEK293

C-6*His

P02743 (H20-V223)

325  [NCBI]

HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV

Approximately 30.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.