PHKG2 Protein, Human (Sf9, GST)

As the catalytic subunit of phosphorylase b kinase (PHK), PHKG2 plays a crucial role in the neural and hormonal regulation of glycogenolysis (glycogen breakdown) by phosphorylating and activating glycogen phosphorylase. Furthermore, PHKG2 has a potential role in regulating testicular glycogenolysis. PHKG2 Protein, Human (Sf9, GST) is the recombinant human-derived PHKG2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PHKG2 Protein, Human (Sf9, GST) is 405 a.a., .

PHKG2 (Phosphorylase Kinase Catalytic Subunit 2) serves as the catalytic subunit of phosphorylase b kinase (PHK), a key enzyme involved in mediating the neural and hormonal regulation of glycogen breakdown (glycogenolysis). Its primary function is to phosphorylate and activate glycogen phosphorylase, playing a central role in the mobilization of glucose from glycogen stores. Besides its involvement in glycogenolysis, PHKG2 may also regulate glycogenolysis specifically in the testis. In vitro studies have shown that PHKG2 phosphorylates PYGM, suggesting potential roles in muscle function or glycogen metabolism beyond its canonical function in glycogenolysis. It has to highlight PHKG2's essential role in regulating glycogenolysis and hints at potential tissue-specific functions in the testis.

Human

Sf9 insect cells

N-GST

P15735 (T2-G406)

5261

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.