PIM3 Protein, Human (Sf9, GST)

The PIM3 protein is a serine/threonine kinase proto-oncogene that is crucial in preventing apoptosis, promoting cell survival, and protein translation in underlying tumorigenesis. It phosphorylates BAD, releases anti-apoptotic Bcl-X(L) and affects cell cycle, protein synthesis and MYC transcriptional activity, showing multifaceted effects on tumorigenesis. PIM3 Protein, Human (Sf9, GST) is the recombinant human-derived PIM3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PIM3 Protein, Human (Sf9, GST) is 325 a.a., .

The PIM3 protein, a proto-oncogene with serine/threonine kinase activity, plays a pivotal role in preventing apoptosis and promoting cell survival and protein translation, potentially contributing to tumorigenesis through various mechanisms. It delivers survival signals by phosphorylating BAD, leading to the release of the anti-apoptotic protein Bcl-X(L). PIM3 regulates cell cycle progression, protein synthesis, and MYC transcriptional activity, highlighting its multifaceted impact on tumorigenesis. Additionally, it negatively regulates insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2) through SOCS6. Beyond its role in tumorigenesis, PIM3 is involved in the control of energy metabolism and regulates AMPK activity, modulating MYC and PPARGC1A protein levels and influencing cell growth.

Human

Sf9 insect cells

N-GST

Q86V86 (L2-L326)

415116

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.