PLVAP Protein, Human (HEK293, His)

The PLVAP protein is an endothelial cell-specific membrane protein that plays a key role in the complex structure of endothelial fenestrae by participating in the formation of septa that bridge these fenestrae. Furthermore, it plays a crucial role in the development of stomata within caveolae and transendothelial channels. PLVAP Protein, Human (HEK293, His) is the recombinant human-derived PLVAP protein, expressed by HEK293 , with N-His labeled tag. The total length of PLVAP Protein, Human (HEK293, His) is 394 a.a., with molecular weight of 50-70 kDa.

Plasmalemma Vesicle-Associated Protein (PLVAP) is a membrane protein exclusive to endothelial cells and is integral to the creation of diaphragms that bridge endothelial fenestrae. It plays a crucial role in the formation of stomata within caveolae and transendothelial channels. PLVAP is essential for regulating microvascular permeability, with endothelial fenestrae facilitating the controlled passage of water and solutes, thereby modulating transcellular versus paracellular flow in various organs. This protein's significance extends to embryonic development, where it performs a specific role. Structurally, PLVAP exists as a homodimer, emphasizing its importance in orchestrating complex endothelial functions (

Human

HEK293

N-His

Q9BX97 (Y49-G442)

83483  [NCBI]

50-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, 200mM L-arginine, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.