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PLVAP Protein, Human (HEK293, His)

Cat. No.: HY-P700879
COA Handling Instructions

The PLVAP protein is an endothelial cell-specific membrane protein that plays a key role in the complex structure of endothelial fenestrae by participating in the formation of septa that bridge these fenestrae. Furthermore, it plays a crucial role in the development of stomata within caveolae and transendothelial channels. PLVAP Protein, Human (HEK293, His) is the recombinant human-derived PLVAP protein, expressed by HEK293 , with N-His labeled tag. The total length of PLVAP Protein, Human (HEK293, His) is 394 a.a., with molecular weight of 50-70 kDa.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
20 μg $230 In-stock
50 μg $435 In-stock
100 μg $700 In-stock
> 100 μg   Get quote  

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  • Biological Activity

  • Technical Parameters

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Description

The PLVAP protein is an endothelial cell-specific membrane protein that plays a key role in the complex structure of endothelial fenestrae by participating in the formation of septa that bridge these fenestrae. Furthermore, it plays a crucial role in the development of stomata within caveolae and transendothelial channels. PLVAP Protein, Human (HEK293, His) is the recombinant human-derived PLVAP protein, expressed by HEK293 , with N-His labeled tag. The total length of PLVAP Protein, Human (HEK293, His) is 394 a.a., with molecular weight of 50-70 kDa.

Background

Plasmalemma Vesicle-Associated Protein (PLVAP) is a membrane protein exclusive to endothelial cells and is integral to the creation of diaphragms that bridge endothelial fenestrae. It plays a crucial role in the formation of stomata within caveolae and transendothelial channels. PLVAP is essential for regulating microvascular permeability, with endothelial fenestrae facilitating the controlled passage of water and solutes, thereby modulating transcellular versus paracellular flow in various organs. This protein's significance extends to embryonic development, where it performs a specific role. Structurally, PLVAP exists as a homodimer, emphasizing its importance in orchestrating complex endothelial functions (

Species

Human

Source

HEK293

Tag

N-His

Accession

Q9BX97 (Y49-G442)

Gene ID
Molecular Construction
N-term
His
PLVAP (Y49-G442)
Accession # Q9BX97
C-term
Synonyms
Plasmalemma vesicle-associated protein; FELS; PV1
Molecular Weight

50-70 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, 200mM L-arginine, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

PLVAP Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
PLVAP Protein, Human (HEK293, His)
Cat. No.:
HY-P700879
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