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  4. PLXDC1 Protein, Human (HEK293, His)

PLXDC1 Protein, Human (HEK293, His)

Cat. No.: HY-P71214
Handling Instructions

PLXDC1 Protein, a cell surface transmembrane protein, that is also a highly expressed protein in the vascular endothelium of human tumors. Under normal and pathological conditions, PLXDC1 is involved in angiogenesis. It is expressed on the surface of tumor cells, that is highly expressed in GC cells and is likely correlated with tumor invasion and migration. The unique angiogenic function of PLXDC1 can be used in tumor anti-angiogenesis and immune research. PLXDC1 Protein, Human (HEK293, His) is the recombinant human-derived PLXDC1 protein, expressed by HEK293 , with C-6*His labeled tag.

For research use only. We do not sell to patients.

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Description

PLXDC1 Protein, a cell surface transmembrane protein, that is also a highly expressed protein in the vascular endothelium of human tumors. Under normal and pathological conditions, PLXDC1 is involved in angiogenesis. It is expressed on the surface of tumor cells, that is highly expressed in GC cells and is likely correlated with tumor invasion and migration. The unique angiogenic function of PLXDC1 can be used in tumor anti-angiogenesis and immune research. PLXDC1 Protein, Human (HEK293, His) is the recombinant human-derived PLXDC1 protein, expressed by HEK293 , with C-6*His labeled tag.
Background

PLXDC1, a cell surface transmembrane protein, that is also a highly expressed protein in the vascular endothelium of human tumors. Under normal and pathological conditions, PLXDC1 is involved in angiogenesis. Pigment epithelium-derived factor binds to PLXDC1 on the cell surface through its extracellular structural domain, thus exerting anti-neoangiogenesis effects and inhibiting tumor growth. PLXDC1 is involved in the development of various cancers. For example, the glioblastoma endothelium drives bevacizumab-induced infiltrative growth through the regulation of PLXDC1. PLXDC1 promotes immune activation and stromal signaling pathways. It is expressed on the surface of tumor cells, that is highly expressed in GC cells and is likely correlated with tumor invasion and migration. PLXDC1 can be used as a biomarker for the prognosis of gastric cancer. The unique angiogenic function of PLXDC1 can be used in tumor anti-angiogenesis and immune research[1][2].
Species

Human
Source

HEK293
Tag

C-6*His
Accession

AAH36059.1 (L19-T426)
Gene ID
Molecular Construction
N-term
PLXDC1 (L19-T426)
Accession # AAH36059.1
6*His
C-term
Synonyms
Plexin Domain-Containing Protein 1; Tumor Endothelial Marker 3; Tumor Endothelial Marker 7; PLXDC1; TEM3; TEM7
AA Sequence

LSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDRTQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQITMATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGT

Molecular Weight

60-90 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

PLXDC1 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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