PMF1 Protein, Human (His, Strep)

The PMF1 protein is part of the MIS12 complex and ensures the correct alignment, segregation and kinetochore formation of chromosomes in mitosis. It also acts as a co-transcriptional partner of NFE2L2, regulating polyamine-induced SSAT transcription. PMF1 Protein, Human (His, Strep) is the recombinant human-derived PMF1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of PMF1 Protein, Human (His, Strep) is 205 a.a., .

PMF1 protein is an integral part of the MIS12 complex, crucial for maintaining normal chromosome alignment and segregation, as well as kinetochore formation during mitosis. Additionally, PMF1 may function as a cotranscription partner of NFE2L2, participating in the regulation of polyamine-induced transcription of SSAT. As a component of the MIS12 complex, PMF1 collaborates with MIS12, DSN1, and NSL1. It exhibits interaction with COPS7A and, notably, binds to the leucine-zipper domain of NFE2L2 via its coiled-coil domain. This interaction with NFE2L2 is essential for the transcriptional regulation of SSAT, emphasizing PMF1's role in coordinating cellular processes related to chromosome dynamics and transcriptional regulation.

Human

E. coli

N-Strep;N-6*His

Q6P1K2 (M1-E205)

100527963

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.