Prokineticin-1/EG-VEGF Protein, Mouse (HEK293, Fc)

Prokineticin-1/EG-VEGF protein induces strong contraction of gastrointestinal smooth muscle and stimulates capillary endothelial cell proliferation, migration, and fenestration. It promotes enteric neural crest cell proliferation and differentiation but not migration. Prokineticin-1/EG-VEGF Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Prokineticin-1/EG-VEGF protein, expressed by HEK293 , with C-hFc labeled tag.

Prokineticin-1/EG-VEGF protein exhibits potent contraction of gastrointestinal (GI) smooth muscle and stimulates the proliferation, migration, and fenestration (formation of membrane discontinuities) in capillary endothelial cells. It also promotes proliferation and differentiation of enteric neural crest cells, but does not affect their migration. Furthermore, Prokineticin-1/EG-VEGF directly contributes to neuroblastoma progression by enhancing the proliferation and migration of neuroblastoma cells. It has a positive regulatory effect on PTGS2 expression and prostaglandin synthesis. In addition, Prokineticin-1/EG-VEGF may have a role in placentation and is implicated in both normal and pathological angiogenesis in the testis.

Mouse

HEK293

C-hFc

Q14A28-1 (A20-F105)

246691  [NCBI]

38-48 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.