1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Carboxypeptidase
  4. PSMB6 Protein, Mouse (His)

PSMB6 Protein, Mouse (His)

Cat. No.: HY-P75989
Handling Instructions

PSMB6 protein is a component of the 20S core proteasome complex and participates in ubiquitin-dependent protein degradation within the 26S proteasome.This complex maintains protein homeostasis by eliminating misfolded or unnecessary proteins.PSMB6 Protein, Mouse (His) is the recombinant mouse-derived PSMB6 protein, expressed by E.coli , with N-His labeled tag.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

PSMB6 protein is a component of the 20S core proteasome complex and participates in ubiquitin-dependent protein degradation within the 26S proteasome.This complex maintains protein homeostasis by eliminating misfolded or unnecessary proteins.PSMB6 Protein, Mouse (His) is the recombinant mouse-derived PSMB6 protein, expressed by E.coli , with N-His labeled tag.

Background

PSMB6, an integral component of the 20S core proteasome complex, takes part in the proteolytic degradation of the majority of intracellular proteins, contributing to essential cellular functions. Its association with two 19S regulatory particles results in the formation of the 26S proteasome, which actively engages in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome is crucial for maintaining protein homeostasis by eliminating misfolded or damaged proteins that could compromise cellular functions, as well as proteins that are no longer needed. Additionally, PSMB6 participates in ubiquitin-independent protein degradation when associated with PA200 or PA28 within the 20S proteasome, playing a pivotal role in processes such as spermatogenesis and the generation of MHC class I-presented antigenic peptides. Within the 20S core complex, PSMB6 exhibits peptidylglutamyl-hydrolyzing activity, also known as postacidic or caspase-like activity, wherein peptide bond hydrolysis occurs directly after acidic residues.

Species

Mouse

Source

E. coli

Tag

N-His

Accession

Q60692 (T34-P238)

Gene ID
Molecular Construction
N-term
His
PSMB6 (T34-P238)
Accession # Q60692
C-term
Synonyms
Proteasome subunit beta type-6; Psmb6; Lmp19
Molecular Weight

Approximately 24.2 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

PSMB6 Protein, Mouse (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
PSMB6 Protein, Mouse (His)
Cat. No.:
HY-P75989
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