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PTHrP Protein, Human (His)

Cat. No.: HY-P702562
Handling Instructions

The PTHrP protein is a key neuroendocrine peptide that regulates multiple cellular processes, including growth, development, migration, differentiation, and survival. It plays an integral role in epithelial calcium transport and key developmental events such as endochondral bone development, mammary gland, and tooth formation. PTHrP Protein, Human (His) is the recombinant human-derived PTHrP protein, expressed by E. coli , with N-6*His labeled tag. The total length of PTHrP Protein, Human (His) is 139 a.a., with molecular weight of 19.7 kDa.

For research use only. We do not sell to patients.

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Description

The PTHrP protein is a key neuroendocrine peptide that regulates multiple cellular processes, including growth, development, migration, differentiation, and survival. It plays an integral role in epithelial calcium transport and key developmental events such as endochondral bone development, mammary gland, and tooth formation. PTHrP Protein, Human (His) is the recombinant human-derived PTHrP protein, expressed by E. coli , with N-6*His labeled tag. The total length of PTHrP Protein, Human (His) is 139 a.a., with molecular weight of 19.7 kDa.

Background

Parathyroid hormone-related protein (PTHrP) emerges as a pivotal neuroendocrine peptide that orchestrates diverse cellular processes, encompassing growth, development, migration, differentiation, and survival, along with its integral role in epithelial calcium ion transport. Its regulatory influence extends to critical developmental events, such as endochondral bone development and the intricate interactions shaping mammary gland and tooth formation. PTHrP's indispensable contribution to skeletal homeostasis underscores its significance in maintaining bone integrity. Within the mammary context, PTHrP plays a multifaceted role, driving mesenchymal differentiation, promoting bud outgrowth, and modulating responsiveness to bone morphogenetic proteins (BMPs), thus intricately shaping mammary tissue architecture. Additionally, PTHrP influences colon cancer cell behavior, enhancing migration and invasion through integrin alpha-6/beta-1-dependent mechanisms. Notably, osteostatin, a derivative of PTHrP, exhibits potent inhibitory effects on osteoclastic bone resorption, emphasizing its role in bone metabolism regulation.

Species

Human

Source

E. coli

Tag

N-6*His

Accession

P12272 (A37-R175)

Gene ID

5744

Molecular Construction
N-term
6*His
PTHrP (A37-R175)
Accession # P12272
C-term
Synonyms
Parathyroid hormone related protein; Parathyroid hormone-like protein; Parathyroid like protein; PLP; PTH related protein; PTH-rP; PTHLH; PTHR; PTHR_HUMAN; PTHrP; PTHrP
Molecular Weight

19.7 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

PTHrP Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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PTHrP Protein, Human (His)
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