PTP4A3 Protein, Human (His)

PTP4A3 Protein, a tyrosine phosphatase, accelerates cell cycle progression from G1 to S phase, fostering cell proliferation, motility, and invasion. Its role extends to promoting cancer metastasis, and it may contribute to cardiac hypertrophy progression by inhibiting intracellular calcium mobilization in response to angiotensin II. PTP4A3 Protein, Human (His) is the recombinant human-derived PTP4A3 protein, expressed by E. coli , with N-His labeled tag. The total length of PTP4A3 Protein, Human (His) is 170 a.a., with molecular weight of 20.29 kDa.

PTP4A3 protein, a member of the protein tyrosine phosphatase family, serves as a critical regulator in cell cycle progression, specifically promoting the transition from G1 to S phase during mitosis. Its influence extends beyond cell cycle dynamics, as it actively enhances cell proliferation, motility, and invasive behavior, thereby contributing to the promotion of cancer metastasis. Additionally, PTP4A3 appears to play a role in the progression of cardiac hypertrophy, potentially through the inhibition of intracellular calcium mobilization in response to angiotensin II. Unraveling the intricate signaling pathways and molecular mechanisms orchestrated by PTP4A3 is crucial for a comprehensive understanding of its diverse roles in cellular processes and pathological conditions.

Human

E. coli

N-His

O75365-1 (M1-C170)

11156  [NCBI]

20.29 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.