RCK Protein, Human (His)

MAP3K19 is a protein kinase involved in intracellular signaling. MAP3K19 can directly activate the ERK and JNK pathways and plays an important role in maintaining the survival of KRAS-mutant lung cancer cells. In addition, MAP3K19 also regulates allergic airway inflammation in patients with asthma by inhibiting airway epithelial responses stimulated by TWEAK, including reduced adhesion factors and production of RANTES, and suppressing allergic airway inflammation in a mouse model of asthma. RCK Protein, Human (His) is the recombinant human-derived RCK protein, expressed by E. coli , with N-6*His labeled tag. The total length of RCK Protein, Human (His) is 305 a.a., .

MAP3K19 can directly activate the ERK and JNK pathways and plays an important role in maintaining the survival of KRAS mutant lung cancer cells^[1].
MAP3K19 plays a role in regulating TGF-β-induced Smad signaling and gene expression^[2].
MAP3K19 can inhibit airway epithelial responses stimulated by TWEAK, including the attenuation of adhesion factors and the production of RANTES, and suppress allergic airway inflammation in a mouse model of asthma, suggesting that MAP3K19 regulates allergic airway inflammation in patients with asthma^[3].

Human

E. coli

N-6*His

Q56UN5 (Q1024-H1328)

80122

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.