Rnase 1 Protein, Human (HEK293, His)

The RNase 1 protein functions as an endonuclease capable of catalyzing RNA cleavage specific to the 3' side of pyrimidine nucleotides. This enzymatic activity extends to single- and double-stranded RNA, demonstrating its versatility in RNA substrate recognition and processing. Rnase 1 Protein, Human (HEK293, His) is the recombinant human-derived Rnase 1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Rnase 1 Protein, Human (HEK293, His) is 128 a.a., with molecular weight of 21-28 kDa.

RNase 1 protein is an endonuclease that plays a crucial role in catalyzing the cleavage of RNA molecules, specifically targeting the 3' side of pyrimidine nucleotides. This enzymatic activity is not limited to a particular RNA conformation, as RNase 1 is known to act on both single-stranded and double-stranded RNA. By facilitating the precise cleavage of RNA molecules, RNase 1 contributes to the regulation and turnover of RNA in cellular processes. Its ability to target pyrimidine-rich regions suggests a broad range of potential substrates, highlighting its importance in RNA metabolism and cellular homeostasis.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

P07998 (K29-T156)

6035  [NCBI]

KESRAKKFQRQHMDSDSSPSSSSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTNGSRYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST

21-28 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 10% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.