RNF113A Protein, Human

RNF113A is an important spliceosome component that participates in pre-mRNA splicing and contributes to U12-type intron splicing within the small spliceosome. As an E3 ubiquitin protein ligase, it catalyzes the transfer of ubiquitin to target proteins. RNF113A Protein, Human is the recombinant human-derived RNF113A protein, expressed by E. coli , with tag free. The total length of RNF113A Protein, Human is 342 a.a., .

RNF113A serves as a vital component of the spliceosome, participating in pre-mRNA splicing processes and contributing to the splicing of U12-type introns as a component of the minor spliceosome. Additionally, RNF113A functions as an E3 ubiquitin-protein ligase, catalyzing the transfer of ubiquitin onto target proteins. Notably, it catalyzes the polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. This multifaceted protein plays a crucial role in DNA repair by synthesizing 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage induced by alkylating agents. Furthermore, RNF113A regulates signaling termination by ubiquitinating CXCR4, leading to its degradation and, consequently, the cessation of CXCR4 signaling.

Human

E. coli

Tag Free

O15541 (A2-T343)

7737

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.