RNF181 Protein, Human

RNF181 Protein, an E3 ubiquitin-protein ligase, mediates the monoubiquitination of the 26S proteasome subunit PSMC2/RPT1. This suggests a role in regulating the 26S proteasome, a vital cellular machinery for protein degradation. RNF181's capacity to modulate PSMC2/RPT1 implies involvement in the intricate regulatory network governing cellular protein homeostasis. RNF181 Protein, Human is the recombinant human-derived RNF181 protein, expressed by E. coli , with tag free. The total length of RNF181 Protein, Human is 152 a.a., .

RNF181 Protein, functioning as an E3 ubiquitin-protein ligase, operates by accepting ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and subsequently directly transferring ubiquitin to its targeted substrates. Notably, RNF181 catalyzes the monoubiquitination of the 26S proteasome subunit PSMC2/RPT1. This activity suggests a role in the regulation of the 26S proteasome, a crucial cellular machinery responsible for protein degradation. The ability of RNF181 to mediate monoubiquitination of PSMC2/RPT1 implies potential involvement in the modulation of proteasomal function, contributing to the intricate regulatory network governing cellular protein homeostasis.

Human

E. coli

Tag Free

Q9P0P0 (A2-T153)

51255

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.