RNF43 Protein, Human (HEK293, Fc)

RNF43 is an E3 ubiquitin protein ligase and a key negative regulator in the Wnt signaling pathway. Its role involves mediating the ubiquitination, endocytosis, and subsequent degradation of components within the Wnt receptor complex, particularly Frizzled. RNF43 Protein, Human (HEK293, Fc) is the recombinant human-derived RNF43 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of RNF43 Protein, Human (HEK293, Fc) is 174 a.a., with molecular weight of ~52 kDa.

RNF43, an E3 ubiquitin-protein ligase, serves as a critical negative regulator of the Wnt signaling pathway by orchestrating the ubiquitination, endocytosis, and subsequent degradation of key components in the Wnt receptor complex, specifically targeting Frizzled. This regulatory activity extends to both canonical and non-canonical Wnt signaling pathways. RNF43's role is underscored by its involvement as part of a master switch, alongside RSPO2 and ZNRF3, governing limb specification. This implies its significance in developmental processes and highlights its multifaceted involvement in modulating Wnt signaling, making it a crucial player in cellular and developmental pathways.

Human

HEK293

C-hFc

Q68DV7 (G24-Y197)

54894  [NCBI]

GFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDY

Approximately 52 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.