RNF43 - ring finger protein 43 Gene

Homo sapiens

Also known as URCC; SSPCS; RNF124

Gene ID: 54894 | Gene type: protein coding

About RNF43

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,352,500-58,417,534 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 105 phenotypes. Broad expression in duodenum (RPKM 7.1), colon (RPKM 6.1) and 24 other tissues.

Summary

The protein encoded by this gene is a RING-type E3 ubiquitin Ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of Frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

RNF43 Products(3)

mRNA	Protein	Name
NM_001305544.2	NP_001292473.1	E3 ubiquitin-protein ligase RNF43 isoform 1 precursor
NM_001305545.1	NP_001292474.1	E3 ubiquitin-protein ligase RNF43 isoform 2
NM_017763.6	NP_060233.3	E3 ubiquitin-protein ligase RNF43 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	22895187	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18313049	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	22575959	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt receptor catabolic process	IDA IDA: Inferred from direct assay	22895187	GOA
involved in negative regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22575959	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	22575959	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	22895187	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22575959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF43 Protein Structure

zf-RING_2

0
200
400
600
783 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF43

RING-type E3 ubiquitin transferase RNF43

RNF43 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF43	Q68DV7	MYADM	Homo sapiens	Q96S97	Anti Tag CoIP	33961781
Intra	RNF43	Q68DV7	UBE2D2	Homo sapiens	P62837	Enzymatic Study	18313049
Intra	RNF43	Q68DV7	UBE2D3	Homo sapiens	P61077	Enzymatic Study	18313049
Intra	RNF43	Q68DV7	UBE2D3	Homo sapiens	P61077	Y2H Array	19690564
Intra	RNF43	Q68DV7	AKAP8L	Homo sapiens	Q9ULX6	Y2H	18313049
Intra	RNF43	Q68DV7	AKAP8L	Homo sapiens	Q9ULX6	Anti Tag CoIP	18313049
Intra	RNF43	Q68DV7	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	18313049

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RNF43 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76007	RNF43 Protein, Human (HEK293, Fc)	Q68DV7 (G24-Y197)	≥95%
HY-P76008	RNF43 Protein, Human (HEK293, His)	Q68DV7-1/NP_060233.3 (G24-Y197)	≥95%

Related Diseases

Diseases

Alias

Sessile Serrated Polyposis Cancer Syndrome

SSPCS	Serrated Polyposis Syndrome
Hyperplastic Polyposis Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Uterine Corpus Endometrial Carcinoma

Pancreatoblastoma

Hereditary Mixed Polyposis Syndrome

Hmps

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Ovarian Cystadenocarcinoma

Cystadenocarcinoma Of Ovary

Cystadenocarcinoma Of The Ovary

Pancreatic Mucinous Cystadenoma

Pancreatic Mucinous Cystic Neoplasm

Pancreatic Mucinous-Cystic Neoplasm

Ovarian Serous Cystadenocarcinoma

Serous Cystadenoma	Cystadenoma Serous
Cystadenoma, Serous

Ovary Adenocarcinoma

Ovarian Adenocarcinoma	Adenocarcinoma Of The Ovary
Ovarian Adenoacanthoma	Adenocarcinoma Of Ovary

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10810	QPH-FR	Inhibitor	/	Unkown
HY-RS12093	RNF43 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF43	RGD	RGD:1305204
Mus musculus	RNF43	MGD	MGI:2442609
Macaca mulatta	RNF43	VGNC	VGNC:99221
Canis familiaris	RNF43	VGNC	VGNC:45671
Felis catus	RNF43	VGNC	VGNC:99434
Bos taurus	RNF43	VGNC	VGNC:34068
Others	RNF43	NCBI

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