SENP5 Protein, Human (GST)

The SENP5 protein is critical in the SUMO pathway and promotes the regulation of SUMOylation through two key functions. First, it processes full-length SUMO3 into its mature form, facilitating the maturation of this ubiquitin-like modifier. SENP5 Protein, Human (GST) is the recombinant human-derived SENP5 protein, expressed by E. coli , with N-GST labeled tag. The total length of SENP5 Protein, Human (GST) is 220 a.a., .

SENP5 protein plays a pivotal role in the SUMO pathway, executing two crucial functions necessary for the regulation of SUMOylation dynamics. Firstly, it facilitates the processing of full-length SUMO3 to its mature form, contributing to the maturation of this small ubiquitin-like modifier. Additionally, SENP5 is actively involved in the deconjugation process, targeting SUMO2 and SUMO3 for removal from modified proteins. Although it exhibits weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates, SENP5's primary impact is on SUMO3-related processes. Its indispensable role in cell division further underscores its significance in fundamental cellular functions. Notably, SENP5 interacts with CCAR2, indicating potential regulatory associations in cellular processes influenced by SUMOylation.

Human

E. coli

N-GST

Q96HI0 (D536-D755)

205564

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.