Serpin A7 Protein, Mouse (HEK293, His)

Serpin A7 protein binds hormones and inhibits serine-type endopeptidase activity. It is involved in negative regulation of endopeptidase activity, response to vitamin A, and thyroid hormone transport. It is located in the extracellular region and is active in the extracellular space. Serpin A7 is orthologous to human SERPINA7 and is expressed primarily in liver E18, liver E14.5, and two other tissues. Serpin A7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A7 protein, expressed by HEK293 , with C-His labeled tag.

The Serpin A7 protein is predicted to possess hormone binding activity as well as serine-type endopeptidase inhibitor activity. It is believed to be involved in various processes, including the negative regulation of endopeptidase activity, response to vitamin A, and thyroid hormone transport. This protein is predicted to be located in the extracellular region and active in the extracellular space. It is orthologous to human SERPINA7 (serpin family A member 7). In terms of expression, it shows biased expression in liver E18, liver E14.5, and two other tissues.

Immobilized Thyroxine-BSA Conjugate at 2.5 μg/mL (100 μL/well) can bind Biotinylated Serpin A7. The ED₅₀ for this effect is 1.317 µg/mL.

Mouse

HEK293

C-His

Q3UEL9/NP_808588.3 (A29-Q426)

331535  [NCBI]

APHNSSEGKVTTCHLPQQNATLYKMPSINADFAFSLYRRLSVENPDLNIFFSPVSISVALAMLSFGSGSSTQTQILEVLGFNLTDTPVTELQQGFQHLICSLNFPKNELELQMGNAVFIGQQLKPLAKFLDDVKTLYETEVFSTDFSNVSAAQHKINSYVEKQTKGKIVGLIQGLKLNIIMILVNYIHFRAQWANPFRVSKTEESSNFSVDKSTTVQVPMMHQLEQYYHYVDMELNCTVLQMDYSENALALFVLPKEGHMEWVEAAMSSKTLKKWNYLLQKGWVELFVPKFSISATYDLGSTLQKMGMRDAFAESADFPGITEDSGLKLSYAFHKAVLHIGEEGTKEGASPEVGSLDQQEVPPLHPVIRLDRAFLLMILEKRTRSVLFLGKLVNPTKQ

Approximately 60-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.