Serpin E2 Protein, Human (HEK293, His)

Serpin E2 is a serine protease inhibitor that inhibits thrombin, trypsin, and urokinase. Its unique role in promoting neurite extension involves specific inhibition of thrombin activity. Serpin E2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E2 Protein, Human (HEK293, His) is 378 a.a., with molecular weight of ~50.0 kDa.

Serpin E2, a serine protease inhibitor, exhibits inhibitory activity towards thrombin, trypsin, and urokinase. Notably, it plays a role in promoting neurite extension by specifically inhibiting thrombin activity. Through its interactions with thrombin, serpin E2 contributes to the regulation of proteolytic processes involved in various cellular functions. Additionally, the protein demonstrates binding affinity for heparin, suggesting its involvement in interactions with glycosaminoglycans and potentially modulating its activity in the context of cellular signaling or other biological processes.

Human

HEK293

C-6*His

P07093-2 (S20-P397)

5270  [NCBI]

SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITRSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP

Approximately 50.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0 or 20 mM PB, 150 mM NaCl, 10% Glycerol, 8% Sucrose, 0.05% Tween 80, pH 7.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.