SERPINE2 - serpin family E member 2 Gene

Homo sapiens

Also known as GDN; PI7; PN1; PNI; PI-7; PN-1; GDNPF

Gene ID: 5270 | Gene type: protein coding

About SERPINE2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:223,975,045-224,039,286 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 36 paralogues. Biased expression in placenta (RPKM 298.6), brain (RPKM 61.2) and 6 other tissues.

Summary

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

SERPINE2 Products(3)

mRNA	Protein	Name
NM_001136528.2	NP_001130000.1	glia-derived nexin isoform b precursor
NM_001136530.1	NP_001130002.1	glia-derived nexin isoform c precursor
NM_006216.4	NP_006207.1	glia-derived nexin isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycosaminoglycan binding	IDA IDA: Inferred from direct assay	19855083	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	1939253	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	3279057	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	3997857	GOA
enables serine-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	19855083	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	17379830	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of blood coagulation	IDA IDA: Inferred from direct assay	17379830	GOA
involved in negative regulation of plasminogen activation	IMP IMP: Inferred from mutant phenotype	19855083	GOA
involved in negative regulation of proteolysis	IDA IDA: Inferred from direct assay	3997857	GOA
involved in positive regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	1691280	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	3279057	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19855083	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	3997857	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	19855083	GOA
located in platelet alpha granule	IMP IMP: Inferred from mutant phenotype	19855083	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINE2 Protein Structure

Serpin

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

glia-derived nexin

glial-derived neurite promoting factor

SERPINE2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINE2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71085	Serpin E2 Protein, Human (HEK293, His)	P07093-2 (S20-P397)	≥95%

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 27

Primary Ciliary Dyskinesia 27	CILD27
Ciliary Dyskinesia, Primary, 27, Without Situs Inversus	Primary Ciliary Dyskinesia 27 Without Situs Inversus
Primary Ciliary Dyskinesia 27 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, 27

Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30	CILD30
Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 30 Without Situs Inversus
Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 30

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Kartagener Syndrome

Kartagener'S Syndrome

Ciliary Dyskinesia, Primary, 1

CILD1	Pcd
Primary Ciliary Dyskinesia 1	Kartagener Syndrome
Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	Immotile Cilia Syndrome
Ics	Polynesian Bronchiectasis
Primary Ciliary Dyskinesia 1 With Or Without Situs Inversus	Ics1
Immotile Cilia Syndrome 1	Primary Ciliary Dyskinesia
KTGS	Dextrocardia-Bronchiectasis-Sinusitis Syndrome
Immotile Cilia Syndrome Kartagener Type	Primary Ciliary Dyskinesia Kartagener Type
Siewert Syndrome	Immotile Cilia
Dyskinesia, Ciliary, Primary, Type 1	Ciliary Motility Disorders

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12723	SERPINE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SERPINE2	VGNC	VGNC:68839
Macaca mulatta	SERPINE2	VGNC	VGNC:77369
Canis familiaris	SERPINE2	VGNC	VGNC:46037
Mus musculus	SERPINE2	MGD	MGI:101780
Bos taurus	SERPINE2	VGNC	VGNC:56144
Rattus norvegicus	SERPINE2	RGD	RGD:3748
Others	SERPINE2	NCBI

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