SGSH Protein, Human (HEK293, His)

SGSH (N-sulfoglucosamine sulfohydrolase) plays a key role in catalyzing specific steps in the lysosomal degradation of heparan sulfate. Through its enzymatic activity, SGSH contributes to the breakdown of heparan sulfate molecules, an important component of the extracellular matrix and cell surfaces. SGSH Protein, Human (HEK293, His) is the recombinant human-derived SGSH protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SGSH Protein, Human (HEK293, His) is 482 a.a., with molecular weight of ~63.0 kDa.

SGSH, or N-sulfoglucosamine sulfohydrolase, plays a critical role in catalyzing a specific step in the degradation process of lysosomal heparan sulfate. Through its enzymatic activity, SGSH contributes to the breakdown of heparan sulfate molecules, which are essential components of the extracellular matrix and cell surface. This degradation process is crucial for maintaining cellular homeostasis and proper functioning of various tissues and organs. Understanding the precise mechanisms and regulation of SGSH-mediated degradation of lysosomal heparan sulfate can provide insights into the pathogenesis and potential therapeutic targets for lysosomal storage disorders associated with heparan sulfate accumulation.

Human

HEK293

C-6*His

P51688 (R21-L502)

6448  [NCBI]

RPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNEL

Approximately 63.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.