SLC11A2 Protein, Human (HEK293, His, MBP, FLAG)

The SLC11A2 protein is a proton-coupled metal ion symporter that selectively transports divalent metal cations, including Cd(2+), Fe(2+), Co(2+), Mn(2+), and less Significant Zn(2+), Ni(2+), VO(2+), the stoichiometric ratio of protons and metal ions is 1:1. It is critical for iron homeostasis, regulating intestinal Fe(2+) absorption, transporting TF-associated endosomal Fe(2+), and promoting Fe(2+) and Mn(2+) entry into mitochondria. SLC11A2 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived SLC11A2 protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag.

The SLC11A2 protein, a proton-coupled metal ion symporter, operates with a proton to metal ion stoichiometry of 1:1, selectively transporting various divalent metal cations with varying affinities, including Cd(2+), Fe(2+), Co(2+), Mn(2+), and less significantly Zn(2+), Ni(2+), VO(2+). It plays a crucial role in maintaining iron homeostasis by modulating the intestinal absorption of dietary Fe(2+) and facilitating the transport of TF-associated endosomal Fe(2+) in erythroid precursors and other cells. Additionally, SLC11A2 facilitates the entry of Fe(2+) and Mn(2+) ions into mitochondria, suggesting its involvement in promoting mitochondrial heme synthesis, iron-sulfur cluster biogenesis, and antioxidant defense. Notably, the protein exhibits the ability to mediate uncoupled fluxes of either protons or metal ions, showcasing its versatile transport capabilities.

Human

HEK293

N-MBP;C-Flag;N-8*His

P49281 (V2-R568)

4891

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.