SLC15A2 Protein, Human (HEK293, His, MBP, FLAG)

The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC15A2 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived SLC15A2 protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC15A2 Protein, Human (HEK293, His, MBP, FLAG) is 728 a.a., .

SLC15A2 protein, a proton-coupled amino-acid transporter, demonstrates a preference for transporting oligopeptides containing 2 to 4 amino acids, with a notable affinity for dipeptides. Its transport activity involves a proton to peptide stoichiometry of 2:1 or 3:1, facilitating the absorption of circulating di- and tripeptides from the glomerular filtrate within the kidney. Beyond its role in peptide transport, SLC15A2 exhibits versatility by transporting various substances, including beta-lactam antibiotics like cefadroxil, other antiviral and anticancer drugs, the dipeptide-like aminopeptidase inhibitor bestatin, and carnosine. Notably, its involvement in innate immunity extends to promoting the detection of microbial pathogens by NOD-like receptors (NLRs), and it mediates the transport of bacterial peptidoglycans across cellular membranes, such as muramyl dipeptide (MDP), a ligand for NOD2, particularly in macrophages.

Human

HEK293

N-MBP;C-Flag;N-8*His

Q16348 (N2-L729)

6565

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.