Sorcin/SRI Protein, Human (sf9, His-GST)

Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation. Sorcin/SRI Protein, Human (sf9, His-GST) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Sorcin/SRI Protein, Human (sf9, His-GST) is 198 a.a., with molecular weight of ~47 kDa.

Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation.

Human

Sf9 insect cells

N-His;N-GST

P30626 (M1-V198)

6717  [NCBI]

Approximately 47 kDa

Greater than 90% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.