2. Gene
  3. SRI - sorcin Gene

SRI - sorcin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SCN; V19; CP22; CP-22

Gene ID: 6717 | Gene type: protein coding

About SRI

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:88,205,115-88,226,976 (from NCBI)

This gene has 10 transcripts (splice variants), 173 orthologues and 20 paralogues. Broad expression in colon (RPKM 86.4), brain (RPKM 64.5) and 24 other tissues.

Summary

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

SRI Products(4)

mRNA Protein Name
NM_001256891.2 NP_001243820.1 sorcin isoform C
NM_001256892.2 NP_001243821.1 sorcin isoform D
NM_003130.4 NP_003121.1 sorcin isoform A
NM_198901.2 NP_944490.1 sorcin isoform B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
17215369 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17699613 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
10748169 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9268363 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
12804766 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of heart rate IMP
IMP: Inferred from mutant phenotype
12754254 GOA
involved in negative regulation of ryanodine-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
17699613 GOA
involved in regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
12754254 GOA
involved in regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
12754254 GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction IMP
IMP: Inferred from mutant phenotype
17130302 GOA
involved in regulation of high voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
12754254 GOA
involved in regulation of relaxation of muscle IMP
IMP: Inferred from mutant phenotype
12754254 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
12754254 GOA
colocalizes with chromaffin granule membrane IDA
IDA: Inferred from direct assay
9268363 GOA
located in cytosol IDA
IDA: Inferred from direct assay
10748169 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10672515 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
15326289 GOA
located in membrane IDA
IDA: Inferred from direct assay
10748169 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRI Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (45 - 101)

EF-hand_7

EF-hand_7: EF-hand domain pair (107 - 161)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

sorcin

22 kDa protein

Recombinant SRI Proteins

Cat. No. Product Name Accession Purity
HY-P77210 Sorcin/SRI Protein, Human (sf9) P30626 (M1-V198) ≥95%
HY-P77211 Sorcin/SRI Protein, Human (sf9, His-GST) P30626 (M1-V198) ≥95%
HY-P700311 Sorcin/SRI Protein, Human (E.coli, GST) P30626 (M1-V198) ≥95%

Related Diseases

Diseases Alias
Overhydrated Hereditary Stomatocytosis

Ohs

Potassium Sodium Disorder Of Erythrocyte

OHST

Stomatocytosis I

Potassium-Sodium Disorder Of Erythrocyte

Stomatocytosisiohst

Hereditary, Overhydrated, Cation-Leak Stomatocytosis

Overhydrated Cation Leak Stomatocytosis

Stomatocytosis, Overhydrated Hereditary
Apical Myocardial Infarction
Severe Congenital Neutropenia

Congenital Neutropenia

Neutropenia, Severe Congenital

Congenital Agranulocytosis

Infantile Genetic Agranulocytosis

Kostmann Disease

Kostmann'S Agranulocytosis

Kostmann'S Syndrome

Severe Infantile Genetic Neutropenia
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100347A SRI-011381 hydrochloride Agonist 99.55% Unkown
HY-19956 GI254023X Inhibitor 99.67% Unkown
HY-100347 SRI-011381 Agonist 99.58% Unkown
HY-142114 SRI-37330 Inhibitor 98.76% Unkown
HY-141623 SRI-37330 hydrochloride Inhibitor 99.55% Unkown
HY-150090 SRI-41315 Activator 99.94% Unkown
HY-114363A SRI 31215 TFA Inhibitor 98.53% Unkown
HY-148853 SRI-42127 Inhibitor 99.80% Unkown
HY-150089 SRI-37240 Modulator 99.21% Unkown
HY-123600 SRI-29329 Inhibitor 99.73% Unkown
HY-117002 SRI 37892 Inhibitor 98.92% Unkown
HY-112580 SRI-31040 / Unkown
HY-126158 SRI-29574 / Unkown
HY-147251 SRI 6409-94 98.60% Unkown
HY-160783 SRI-43265 Inhibitor 99.08% Unkown
HY-RS13767 SRI Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-117902 SRI-31142 / Unkown
HY-N9533 16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRI RGD RGD:1584485
Canis familiaris SRI VGNC VGNC:46804
Macaca mulatta SRI VGNC VGNC:81763
Mus musculus SRI MGD MGI:98419
Felis catus SRI VGNC VGNC:65681
Bos taurus SRI VGNC VGNC:35281
Macaca fascicularis SRI NCBI NCBI:102138728
Others SRI NCBI