Sox2 Protein, Human

Sox2 protein is a key transcription factor that forms a trimeric complex with OCT4 and controls the expression of genes critical for embryonic development (YES1, FGF4, UTF1, ZFP206). It binds the NANOG enhancer and is critical for early embryogenesis and stem cell pluripotency. Sox2 Protein, Human is the recombinant human-derived Sox2 protein, expressed by E. coli , with tag free. The total length of Sox2 Protein, Human is 84 a.a., .

Sox2, a pivotal transcription factor, forms a trimeric complex with OCT4 on DNA, exerting control over the expression of genes crucial in embryonic development, such as YES1, FGF4, UTF1, and ZFP206. It binds to the proximal enhancer region of NANOG, playing a critical role in early embryogenesis and maintaining embryonic stem cell pluripotency. Functioning as a downstream target of SRRT, Sox2 contributes to the promotion of neural stem cell self-renewal while preventing neural cell differentiation through counteraction against proneural proteins. Additionally, it may serve as a switch in neuronal development. Sox2 engages in various interactions, including those with ZSCAN10, SOX3, FGFR1, GLIS1, POU5F1, DDX56, L3MBTL3, DCAF5, RCOR1/CoREST, PHF20L1, and TRIM26, underscoring its dynamic regulatory network. These interactions highlight its involvement in critical cellular processes, including ubiquitination, degradation protection, and prevention of ubiquitination by specific ligases.

Human

E. coli

Tag Free

P48431 (R40-D123)

6657

Approximately 10.4 KDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 50 mM Tris, pH7.5, 150 mM NaCl, 5% glycerol.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.