STAB2 - stabilin 2 Gene

Homo sapiens

Also known as FEX2; HARE; FEEL2; FELL2; FELE-2; SCARH1

Gene ID: 55576 | Gene type: protein coding

About STAB2

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:103,587,273-103,766,719 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 2 paralogues. Biased expression in spleen (RPKM 18.3), liver (RPKM 4.3) and 2 other tissues.

Summary

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]

STAB2 Products(1)

mRNA	Protein	Name
NM_017564.10	NP_060034.9	stabilin-2 precursor

STAB2 Protein Structure

EGF_3

Fasciclin

EGF_3

Fasciclin

EGF_3

Fasciclin

EGF_3

Xlink

Fasciclin

0
400
800
1200
1600
2000
2400
2551 a.a.

Protein Preferred Names

Protein Names

stabilin-2

CD44-like precursor FELL

Recombinant STAB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79135	Stabilin-2 Protein, Human (His)	Q8WWQ8 (G2198-V2295)	≥95%

Related Diseases

Diseases

Alias

Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome	CFZS
Congenital Nonprogressive Myopathy With Moebius And Robin Sequences	Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence
Cfz Syndrome	Carey Fineman Ziter Syndrome
Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences	Myopathy-Moebius-Robin Syndrome
CFZS1	Moebius Sequence, Robin Complex, And Hypotonia
Congenital Non-Progressive Myopathy With Moebius And Robin Sequences

Factor Viii Deficiency

Autosomal Hemophilia A	Hemophilia A
Autosomal Factor Viii Deficiency	Classic Hemophilia A
Congenital Factor Viii Disorder	Subhemophilia
Factor 8 Deficiency, Congenital	Factor Viii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13862	STAB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STAB2	VGNC	VGNC:77957
Felis catus	STAB2	VGNC	VGNC:65740
Rattus norvegicus	STAB2	RGD	RGD:628822
Bos taurus	STAB2	VGNC	VGNC:35349
Canis familiaris	STAB2	VGNC	VGNC:46869
Mus musculus	STAB2	MGD	MGI:2178743
Others	STAB2	NCBI

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