TEC Protein, Human (Sf9)

TEC proteins are dynamic nonreceptor tyrosine kinases that transduce signals in a variety of cellular processes. In adaptive immunity, TEC regulate T cell development, affecting IL2 gene induction and CD28 signaling. TEC Protein, Human (Sf9) is the recombinant human-derived TEC protein, expressed by Sf9 insect cells , with tag free. The total length of TEC Protein, Human (Sf9) is 630 a.a., .

TEC protein, a non-receptor tyrosine kinase, serves as a versatile signal transducer in various cellular processes. Crucial in adaptive immunity, TEC regulates T-cell development, function, and differentiation, impacting IL2 gene induction and CD28 signaling. It collaborates with ITK and BTK in T-cell and B-cell responses, respectively, influencing BCR signaling and cytokine production in mast cells. Additionally, TEC plays a role in myeloid cell growth and differentiation through CSF3 activation, participates in platelet signaling, and cooperates with JAK2 in FOS transcription activation. Notably, TEC is implicated in hepatocyte proliferation, liver regeneration, and regulates FGF2 secretion through unconventional pathways. Its involvement in G protein-coupled receptor and integrin-mediated signaling in platelets, along with a potential role in osteoclast differentiation, underscores the multifaceted contributions of TEC to diverse cellular mechanisms.

Human

Sf9 insect cells

Tag Free

P42680 (N2-R631)

7006

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.