TEM8/ANTXR1 Protein, Human (HEK293, Fc)

The TEM8/ANTXR1 protein is multifunctional in cell attachment and migration, interacting with extracellular matrix proteins and the actin cytoskeleton. This binding mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeletal reorganization and cell spreading, which is critical for cell structure and movement. TEM8/ANTXR1 Protein, Human (HEK293, Fc) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293 , with C-hFc labeled tag.

TEM8/ANTXR1, a multifaceted protein, actively participates in cell attachment and migration. It engages with both extracellular matrix proteins and the actin cytoskeleton, mediating cell adhesion to type 1 collagen and gelatin. This interaction facilitates the reorganization of the actin cytoskeleton and promotes cell spreading, underscoring its crucial role in cellular architecture and motility. Additionally, TEM8/ANTXR1 contributes to the angiogenic response of cultured umbilical vein endothelial cells, emphasizing its involvement in vascular development. Notably, in microbial infection scenarios, TEM8/ANTXR1 serves as a receptor for the protective antigen (PA) of Bacillus anthracis, highlighting its dual role in cellular processes and host-pathogen interactions.

Human

HEK293

C-hFc

Q9H6X2-1 (E33-S321)

84168  [NCBI]

Approximately 69 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.