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  4. TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His)

TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P701042
Handling Instructions

HAVCR1 is a co-stimulatory molecule expressed on the surface of immune cells, which promotes the activation and proliferation of immune cells, promotes the secretion of cytokines, and regulates immune response. HAVCR1 affects tumor progression and patient prognosis by inhibiting the MEK/ERK pathway. TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) is 320 a.a., with molecular weight of 100-150 kDa.

For research use only. We do not sell to patients.

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Description

HAVCR1 is a co-stimulatory molecule expressed on the surface of immune cells, which promotes the activation and proliferation of immune cells, promotes the secretion of cytokines, and regulates immune response. HAVCR1 affects tumor progression and patient prognosis by inhibiting the MEK/ERK pathway. TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) is 320 a.a., with molecular weight of 100-150 kDa.
Background

Hepatitis A virus-cell receptor (HAVCR1), also known as T cell immunoglobulin mucin receptor 1 (TIM-1) and kidney damage molecule 1 (KIM-1). HAVCR1 is a co-stimulatory molecule expressed on the surface of immune cells, which promotes the activation and proliferation of immune cells, promotes the secretion of cytokines, and regulates immune response. HAVCR1 affects tumor progression and patient prognosis by inhibiting the MEK/ERK pathway[1][2].
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

A0A2K5WXJ6 (V23-G342)
Gene ID

/
Molecular Construction
N-term
TIM-1 (V23-G342)
Accession # A0A2K5WXJ6
His
C-term
Synonyms
HAVcr-1; KIM-1; KIM1; TIMD-1; TIMD1; TIM; TIM-1; TIM1; CD365; HAVCR1; HAVCR; HAVCR-1
Molecular Weight

100-150 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TIM-1/KIM-1/HAVCR Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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