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  4. TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc)

TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc)

Cat. No.: HY-P73601
Handling Instructions

TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that plays a crucial regulatory role in regulatory B cells, affecting their generation, expansion and inhibitory functions. It acts as a ligand for P-selectin/SELPLG and controls activated T cell trafficking during inflammatory responses. TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) is the recombinant rat-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-hFc, C-His labeled tag.

For research use only. We do not sell to patients.

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Description

TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that plays a crucial regulatory role in regulatory B cells, affecting their generation, expansion and inhibitory functions. It acts as a ligand for P-selectin/SELPLG and controls activated T cell trafficking during inflammatory responses. TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) is the recombinant rat-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-hFc, C-His labeled tag.
Background

TIM-1/KIM-1/HAVCR Protein serves as a phosphatidylserine receptor with a crucial functional role in the homeostasis of regulatory B-cells, influencing their generation, expansion, and suppressor functions. Additionally, as a ligand for P-selectin/SELPLG, it assumes a specialized role in the trafficking of activated T-cells during inflammatory responses, particularly controlling T-cell accumulation in the inflamed central nervous system and influencing the induction of autoimmune disease. TIM-1/KIM-1/HAVCR also regulates the expression of various anti-inflammatory cytokines and co-inhibitory ligands, including IL10, acting as a modulator of T-cell proliferation. Furthermore, it may play a role in kidney injury and repair. Interactions with STAM and SELPLG contribute to the multifaceted regulatory functions of TIM-1/KIM-1/HAVCR Protein.
Species

Rat
Source

HEK293
Tag

N-hFc;C-His
Accession

O54947/NP_775172.1 (S18-V238)
Gene ID
Molecular Construction
N-term
hFc
TIM-1 (S18-V238)
Accession # O54947/NP_775172.1
His
C-term
Synonyms
Hepatitis A virus cellular receptor 1; HAVcr-1; KIM-1; TIM-1; CD365; HAVCR1
Molecular Weight

90-100 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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