TMEM219/IGFBP-3R Protein, Human (HEK293, Fc)

The TMEM219/IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This protein actively binds to IGFBP3, forming a key molecular interaction that may initiate the apoptosis signaling pathway. TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is the recombinant human-derived TMEM219/IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is 166 a.a., with molecular weight of 60-70 kDa.

TMEM219, also known as IGFBP-3R, serves as a cell death receptor with specificity for insulin-like growth factor binding protein 3 (IGFBP3). This receptor is implicated in potentially mediating caspase-8-dependent apoptosis upon binding with its ligand, IGFBP3. The direct interaction between TMEM219 and IGFBP3 underscores its role in transducing signals related to cell survival and death pathways. Additionally, TMEM219 interacts with caspase-8, further suggesting its involvement in regulating apoptotic processes, potentially through the caspase-8-dependent pathway.

Human

HEK293

C-hFc

Q86XT9 (S39-R204)

124446  [NCBI]

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.