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  3. TREML2 Protein, Mouse (HEK293, His)

TREML2 Protein, Mouse (HEK293, His)

Cat. No.: HY-P71384
Handling Instructions

TREML2 protein acts as a cell surface receptor for SEMA6A and affects key intercellular signaling in cerebellar development. It regulates granule cell migration, coordinates actin cytoskeletal reorganization, and contributes significantly to axonal guidance in the central nervous system. TREML2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREML2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREML2 Protein, Mouse (HEK293, His) is 246 a.a., with molecular weight of 58-62 kDa.

For research use only. We do not sell to patients.

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Description

TREML2 protein acts as a cell surface receptor for SEMA6A and affects key intercellular signaling in cerebellar development. It regulates granule cell migration, coordinates actin cytoskeletal reorganization, and contributes significantly to axonal guidance in the central nervous system. TREML2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREML2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREML2 Protein, Mouse (HEK293, His) is 246 a.a., with molecular weight of 58-62 kDa.

Background

Semaphorin-6A/SEMA6A serves as a cell surface receptor for PLXNA2 and plays a crucial role in cell-cell signaling, particularly in the regulation of granule cell migration during cerebellar development. It orchestrates the reorganization of the actin cytoskeleton and functions as a significant contributor to axon guidance within the developing central nervous system, exhibiting repulsive action towards migrating granular neurons. Additionally, SEMA6A is implicated in channeling sympathetic axons into sympathetic chains and controlling the temporal sequence of sympathetic target innervation. In the context of microbial infection, SEMA6A acts as a receptor for P.sordellii toxin TcsL in the vascular system, underscoring its diverse roles in both developmental processes and response to external stimuli.

Species

Mouse

Source

HEK293

Tag

C-6*His

Accession

Q2LA85 (H25-A270)

Gene ID
Molecular Construction
N-term
TREML2 (H25-A270)
Accession # Q2LA85
6*His
C-term
Synonyms
Trem-like transcript 2 protein; TLT-2; Triggering receptor expressed on myeloid cells-like protein 2; TREML2; TLT2
AA Sequence

HSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPA

Molecular Weight

58-62 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

TREML2 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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TREML2 Protein, Mouse (HEK293, His)
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HY-P71384
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