1. Recombinant Proteins
  2. Enzymes & Regulators Ubiquitin Related Proteins
  3. Transferases (EC 2) Ubiquitin Enzymes
  4. E3 Ligases
  5. TRIM/RBCC Proteins
  6. TRIM3 Protein, Human

TRIM3 Protein, Human

Cat. No.: HY-P701505
Handling Instructions

TRIM3 protein is an E3 ubiquitin ligase that regulates neuronal plasticity, learning, and memory. TRIM3 Protein, Human is the recombinant human-derived TRIM3 protein, expressed by E. coli , with tag free. The total length of TRIM3 Protein, Human is 743 a.a., .

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

TRIM3 protein is an E3 ubiquitin ligase that regulates neuronal plasticity, learning, and memory. TRIM3 Protein, Human is the recombinant human-derived TRIM3 protein, expressed by E. coli , with tag free. The total length of TRIM3 Protein, Human is 743 a.a., .

Background

TRIM3, an E3 ubiquitin ligase, assumes crucial roles in neuronal functions, orchestrating the regulation of neuronal plasticity, learning, and memory. Beyond its neuronal involvement, TRIM3 extends its influence to various biological processes, including innate immunity and cell cycle regulation. Within neurons, it becomes a key component of the cytoskeleton-associated recycling or transport complex, exerting its regulatory role by polyubiquitinating gamma-actin and thereby influencing neuronal plasticity. Additionally, TRIM3 ubiquitinates the postsynaptic scaffold GKAP, contributing to synaptic remodeling and modulation of dendritic spine morphology. It positively regulates the motility of the microtubule-dependent motor protein KIF21B. Moreover, TRIM3, through its RING-dependent E3 ligase activity, induces growth arrest and ubiquitinates CDKN1A. In the realm of innate immunity, it plays a positive regulatory role in TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3, subsequently facilitating the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes.

Species

Human

Source

E. coli

Tag

Tag Free

Accession

O75382 (A2-Q744)

Gene ID

10612

Molecular Construction
N-term
TRIM3 (A2-Q744)
Accession # O75382
C-term
Synonyms
TRIM3; Tripartite motif-containing protein 3; Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97
Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TRIM3 Protein, Human
Cat. No.:
HY-P701505
Quantity:
MCE Japan Authorized Agent: