TRIM69 Protein, Human (GST)

TRIM69 protein is an E3 ubiquitin ligase that limits viral infection (such as dengue virus, Indiana vesicular stomatitis virus) by ubiquitinating viral proteins such as dengue virus NS3, thereby limiting infection. TRIM69 Protein, Human (GST) is the recombinant human-derived TRIM69 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRIM69 Protein, Human (GST) is 499 a.a., .

TRIM69, functioning as an E3 ubiquitin ligase, assumes a pivotal role in antiviral immunity by exerting restrictions on various viral infections, including dengue virus and vesicular stomatitis Indiana virus. This regulatory function is achieved through the ubiquitination of viral proteins, such as dengue virus NS3, thereby curbing the extent of infection. Beyond its antiviral role, TRIM69 emerges as a central mediator in type I interferon-induced microtubule stabilization, establishing a direct association with microtubules independently of its E3 ligase activity. Furthermore, it contributes to cataract formation in conjunction with TP53. Mechanistically, TRIM69 inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination, highlighting its multifaceted involvement in cellular processes.

Human

E. coli

N-GST

Q86WT6 (E2-Q500)

140691

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.