TrkB Protein, Canine (HEK293, Fc)

TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag.

TrkB protein has a high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation^[1].
TrkB protein is involved in epithelial-mesenchymal transition associated with increased migration and invasion in many cancer cell lines^[3].
Abnormal activation caused by overexpression or fusion of TrkB protein can promote the genesis, progression, and treatment resistance of various types of neurogenic tumors^[5].
Dysregulation of TrkB protein is associated with the pathogenesis of many diseases, such as neurodegenerative diseases, angiogenesis, lung adenocarcinoma, and gastric cancer^[2][3][4].

Canine

HEK293

C-hFc

A0A8C0LGP8/XP_541264.2 (C32-H430)

484147  [NCBI]

Approximately 71.2 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.