TTK Protein, Human (Sf9, GST, FLAG)

The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (Sf9, GST, FLAG) is the recombinant human-derived TTK protein, expressed by Sf9 insect cells , with C-Flag, N-GST labeled tag and K857G, , , , mutation. The total length of TTK Protein, Human (Sf9, GST, FLAG) is 857 a.a., .

TTK, a proficient kinase, exhibits versatile substrate specificity by phosphorylating proteins on serine, threonine, and tyrosine residues. Implicating its role in cell proliferation, TTK likely plays a crucial part in regulating fundamental cellular processes. Notably, TTK phosphorylates MAD1L1, thereby promoting mitotic checkpoint signaling, a pivotal mechanism for ensuring accurate chromosome segregation during cell division. Additionally, TTK's significance extends to chromosome alignment, where it enhances the activity of AURKB by directly phosphorylating CDCA8 at the centromere. The intricate involvement of TTK in mitotic processes underscores its essential role in safeguarding genomic stability and orchestrating key events during cell division.

Human

Sf9 insect cells

C-Flag;N-GST

P33981 (M1-K857, K857G)

7272

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.