TYRO3/DTK Protein, Mouse (HEK293, His)

TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation.Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules.TYRO3/DTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-His labeled tag.

The TYRO3/DTK protein, a receptor tyrosine kinase, transduces signals from the extracellular matrix by binding to various ligands, including TULP1 or GAS6. It plays a crucial role in regulating numerous physiological processes, encompassing cell survival, migration, and differentiation. Upon ligand binding at the cell surface, TYRO3 undergoes dimerization and autophosphorylation on its intracellular domain, creating docking sites for downstream signaling molecules. Upon activation, TYRO3 interacts with PIK3R1, enhancing PI3-kinase activity and activating the AKT survival pathway, leading to nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling is implicated in processes such as neuron protection from excitotoxic injury, platelet aggregation, and cytoskeleton reorganization. Additionally, TYRO3 plays a crucial role in inhibiting Toll-like receptors (TLRs)-mediated innate immune responses by activating STAT1, which selectively induces the production of suppressors of cytokine signaling SOCS1 and SOCS3.

Mouse

HEK293

C-His

P55144-2 (R31-D419)

22174  [NCBI]

60-75 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.