UCHL5 Protein, Human

UCHL5 is a highly specific protease that acts as a deubiquitinating enzyme intricately linked to the 19S proteasome subunit, cleaving "Lys-48" linked polyubiquitin chains. Although the INO80 complex is inert, transient interactions between INO80 and the proteasome (facilitated by ADRM1) activate UCHL5. UCHL5 Protein, Human is the recombinant human-derived UCHL5 protein, expressed by E. coli , with tag free. The total length of UCHL5 Protein, Human is 328 a.a., .

UCHL5, a protease of notable specificity, is tasked with the cleavage of 'Lys-48'-linked polyubiquitin chains, operating as a deubiquitinating enzyme intricately associated with the 19S regulatory subunit of the 26S proteasome. While positioned as a putative regulatory component within the INO80 complex, UCHL5 remains inactive within this context. However, a transient interaction between the INO80 complex and the proteasome, facilitated by ADRM1, serves as the key activator for UCHL5, unlocking its deubiquitinating prowess. This nuanced regulatory role highlights UCHL5's participation in the dynamic interplay between ubiquitin-dependent processes and the proteasomal machinery.

Human

E. coli

Tag Free

Q9Y5K5 (T2-K329)

51377

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.