1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Endothelial cell CD Proteins
  4. U-PAR/CD87
  5. uPAR Protein, Cynomolgus (HEK293, His)

uPAR protein is the receptor of urokinase plasminogen activator and plays an important role in localizing and promoting the formation of plasmin. It mediates proteolysis-independent signal transduction through U-PA and is regulated through negative feedback. uPAR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived uPAR protein, expressed by HEK293 , with C-His labeled tag. The total length of uPAR Protein, Cynomolgus (HEK293, His) is 283 a.a., with molecular weight of 60-70 kDa.

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Description

uPAR protein is the receptor of urokinase plasminogen activator and plays an important role in localizing and promoting the formation of plasmin. It mediates proteolysis-independent signal transduction through U-PA and is regulated through negative feedback. uPAR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived uPAR protein, expressed by HEK293 , with C-His labeled tag. The total length of uPAR Protein, Cynomolgus (HEK293, His) is 283 a.a., with molecular weight of 60-70 kDa.

Background

uPAR Protein serves as a receptor for urokinase plasminogen activator, playing a crucial role in localizing and facilitating plasmin formation. Additionally, it mediates the proteolysis-independent signal transduction activation effects of U-PA. Subject to negative-feedback regulation by U-PA, uPAR undergoes cleavage into an inactive form. It typically exists as a monomer, and interacts with various proteins, including SRPX2 and MRC2. Notably, it forms a complex with FAP (seprase) at the cell surface of invadopodia membrane, contributing to cellular processes involved in proteolysis and signaling. Moreover, uPAR engages in a ternary complex with PLAU (urokinase-type plasminogen activator) and SERPINE1, and this complex also interacts with SORL1, further highlighting its multifaceted interactions in cellular functions.

Species

Cynomolgus

Source

HEK293

Tag

C-His

Accession

Q9GK78 (L23-G305)

Gene ID
Molecular Construction
N-term
uPAR (L23-G305)
Accession # Q9GK78
His
C-term
Synonyms
U-PAR; uPAR; CD87; PLAUR; MO3; UPAR
Molecular Weight

60-70 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

uPAR Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
uPAR Protein, Cynomolgus (HEK293, His)
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HY-P700897
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