uPAR Protein, Cynomolgus (HEK293, His)

uPAR Protein, a receptor for urokinase plasminogen activator, crucially localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction by U-PA, regulated through negative feedback. uPAR, typically a monomer, interacts with SRPX2, MRC2, and forms a complex with FAP at invadopodia, contributing to proteolysis and signaling. It engages in a ternary complex with PLAU and SERPINE1, also interacting with SORL1, highlighting multifaceted cellular functions. uPAR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Cynomolgus (HEK293, His) is 283 a.a., with molecular weight of 60-70 kDa.

uPAR Protein serves as a receptor for urokinase plasminogen activator, playing a crucial role in localizing and facilitating plasmin formation. Additionally, it mediates the proteolysis-independent signal transduction activation effects of U-PA. Subject to negative-feedback regulation by U-PA, uPAR undergoes cleavage into an inactive form. It typically exists as a monomer, and interacts with various proteins, including SRPX2 and MRC2. Notably, it forms a complex with FAP (seprase) at the cell surface of invadopodia membrane, contributing to cellular processes involved in proteolysis and signaling. Moreover, uPAR engages in a ternary complex with PLAU (urokinase-type plasminogen activator) and SERPINE1, and this complex also interacts with SORL1, further highlighting its multifaceted interactions in cellular functions.

Cynomolgus

HEK293

C-His

Q9GK78 (L23-G305)

102139334  [NCBI]

60-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.