1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Endothelial cell CD Proteins
  4. U-PAR/CD87
  5. uPAR Protein, Human (Domain 2&3 , HEK293, His)

uPAR Protein, Human (Domain 2&3 , HEK293, His)

Cat. No.: HY-P700845
Handling Instructions

uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 2&3, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 2&3, HEK293, His) is 191 a.a., with molecular weight of 33-45 kDa.

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Description

uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 2&3, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 2&3, HEK293, His) is 191 a.a., with molecular weight of 33-45 kDa.

Background

uPAR Protein functions as a receptor for urokinase plasminogen activator, actively participating in the localization and facilitation of plasmin formation. Additionally, it serves as a mediator of the proteolysis-independent signal transduction activation effects induced by U-PA. Subject to negative-feedback regulation by U-PA, uPAR Protein undergoes cleavage into an inactive form. Typically existing as a monomer, it interacts with various proteins, including MRC2, SRPX2 (via the UPAR/Ly6 domains), and FAP (seprase), with the latter interaction occurring at the cell surface of invadopodia membrane. Moreover, uPAR Protein engages in an interaction with SORL1, specifically through the N-terminal ectodomain, and this interaction has been associated with a decrease in PLAUR internalization. Notably, the formation of a ternary complex composed of PLAUR, PLAU (urokinase-type plasminogen activator), and SERPINE1 also involves an interaction with SORL1.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q03405-1 (L115-G305)

Gene ID
Molecular Construction
N-term
uPAR (L115-G305)
Accession # Q03405-1
His
C-term
Synonyms
U-PAR; uPAR; CD87; PLAUR; MO3; UPAR
Molecular Weight

33-45 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

uPAR Protein, Human (Domain 2&3 , HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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uPAR Protein, Human (Domain 2&3 , HEK293, His)
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HY-P700845
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