WDHD1 Protein, Human (HEK293, His, Strep)

WDHD1 Protein is a core replisome component that serves as a replication initiation factor. It directly binds to the CMG complex, acting as a hub to recruit other proteins to the replication fork. WDHD1 interacts with POLA1, MCM10, DNA2, CDC45, and GINS2, linking it to the CMG helicase complex. WDHD1 Protein, Human (HEK293, His, Strep) is the recombinant human-derived WDHD1 protein, expressed by HEK293 , with N-10*His, N-Strep labeled tag. The total length of WDHD1 Protein, Human (HEK293, His, Strep) is 1128 a.a., .

WDHD1, a core replisome component, assumes a pivotal role as a replication initiation factor by directly binding to the CMG complex. Its function extends beyond initiation, serving as a central hub for recruiting additional proteins to the replication fork. In its trimeric form, WDHD1 engages in interactions with various essential components of the replisome, such as the polymerase alpha catalytic subunit POLA1, MCM10, DNA2, CDC45, and the GINS2 subunit of the GINS complex. These interactions intricately link WDHD1 to the CMG helicase complex, highlighting its essential role in orchestrating the assembly and coordination of the molecular machinery involved in DNA replication. The multifaceted interactions of WDHD1 underscore its significance in facilitating the dynamic processes of DNA replication at the molecular level.

Human

HEK293

N-10*His;N-Strep

O75717 (P2-E1129)

11169

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.