ZNRF2 Protein, Human (His)

ZNRF2 protein is an E3 ubiquitin protein ligase that plays a crucial role in neuronal transmission and plasticity. It ubiquitinates Na(+)/K(+) ATPase α-1 subunit/ATP1A1, affecting its endocytosis or degradation, which is critical for neuronal function. ZNRF2 Protein, Human (His) is the recombinant human-derived ZNRF2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNRF2 Protein, Human (His) is 241 a.a., .

ZNRF2 Protein, an E3 ubiquitin-protein ligase, assumes a crucial role in the establishment and maintenance of neuronal transmission and plasticity. One of its key functions involves the ubiquitination of the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1, thereby influencing its endocytosis and/or degradation, a process integral to neuronal function. Additionally, ZNRF2 serves as a positive regulator of mTORC1 activation in response to amino acids, operating upstream of both the V-ATPase and Rag-GTPases. This regulatory cascade, however, exhibits a self-regulating feedback mechanism, as mTOR phosphorylation of ZNRF2 leads to its inhibition and subsequent targeting to the cytosol. This intricate interplay highlights ZNRF2's multifaceted role in modulating neuronal processes, emphasizing its significance in neuronal transmission and plasticity.

Human

E. coli

N-6*His

Q8NHG8 (G2-D242)

/

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.