ZRANB1 Protein, Human (Sf9)

ZRANB1 is a ubiquitin thioesterase that specifically hydrolyzes “Lys-29”-linked and “Lys-33”-linked diubiquitins, with additional activity on “Lys-63”-linked chains. It positively regulates the Wnt pathway by deubiquitinating APC, an inhibitor of Wnt-mediated transcription. ZRANB1 Protein, Human (Sf9) is the recombinant human-derived ZRANB1 protein, expressed by Sf9 insect cells , with tag free. The total length of ZRANB1 Protein, Human (Sf9) is 708 a.a., .

ZRANB1, functioning as a ubiquitin thioesterase, demonstrates specificity in hydrolyzing 'Lys-29'-linked and 'Lys-33'-linked diubiquitin, with additional activity in cleaving 'Lys-63'-linked chains, albeit less efficiently. Notably, ZRANB1 acts as a positive regulator of the Wnt signaling pathway by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. Moreover, it plays a pivotal role in autophagy regulation through the deubiquitination of PIK3C3/VPS34, facilitating autophagosome maturation. Beyond its involvement in intracellular processes, ZRANB1 is implicated in the modulation of cell morphology and cytoskeletal organization, contributing to stress fiber dynamics and cell migration.

Human

Sf9 insect cells

Tag Free

Q9UGI0 (M1-E708)

54764

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.