1. Autophagy MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  2. VEGFR Autophagy PDGFR Raf RET FGFR c-Kit Tie
  3. Regorafenib monohydrate (Standard)

Regorafenib monohydrate (Standard) 

Cat. No.: HY-10331AR Purity: ≥98%
Handling Instructions

Regorafenib (monohydrate) (Standard) is the analytical standard of Regorafenib (monohydrate). This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity.

For research use only. We do not sell to patients.

Regorafenib monohydrate (Standard) Chemical Structure

Regorafenib monohydrate (Standard) Chemical Structure

CAS No. : 1019206-88-2

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Description

Regorafenib (monohydrate) (Standard) is the analytical standard of Regorafenib (monohydrate). This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity.

Molecular Weight

500.83

Formula

C21H17ClF4N4O4

CAS No.
SMILES

O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F.O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Regorafenib monohydrate (Standard)
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