RepSox hydrochloride (Synonyms: E-616452 hydrochloride; SJN 2511 hydrochloride)

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RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.

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RepSox hydrochloride Chemical Structure

CAS No. : 2319939-07-4

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Other In-stock Forms of RepSox hydrochloride:

RepSox

Other Forms of RepSox hydrochloride:

RepSox In-stock

20 Publications Citing Use of MCE RepSox hydrochloride

: RepSox hydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jun 19;8(36):60159-60172. [Abstract]; SH-SY5Y (A) and HEK293 cells (B) are treated with 25 μM RepSox (Rep) in absence or presence of dPA or dPPA for 72 h, and the Western blotting results show that dPA or dPPA increases the expression in the presence of RepSox. RepSox does not cause significant alteration of furin protein compared to control. The expression of furin remains significantly increased after dPA or dPPA in the presence of RepSox.

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Description	RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.
Molecular Weight	323.78
Formula	C₁₇H₁₄ClN₅
CAS No.	2319939-07-4
SMILES	CC1=NC(C2=NNC=C2C3=CC=C4N=CC=CC4=N3)=CC=C1.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506. [Content Brief]

RepSox hydrochloride Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RepSox2319939-07-4E-616452SJN 2511E616452E 616452SJN2511SJN-2511TGF-beta/SmadAnaplastic lymphoma kinase (ALK)Transforming growth factor betaAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Inhibitorinhibitorinhibit

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RepSox hydrochloride (Synonyms: E-616452 hydrochloride; SJN 2511 hydrochloride)

Other Forms of RepSox hydrochloride:

RepSox hydrochloride Related Antibodies

20 Publications Citing Use of MCE RepSox hydrochloride

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

RepSox hydrochloride Related Classifications

Molarity Calculator

Dilution Calculator