2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Resolvin D1

Resolvin D1  (Synonyms: RvD1)

Cat. No.: HY-125527 Purity: ≥99.0%
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Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages.

For research use only. We do not sell to patients.

Resolvin D1 Chemical Structure

Resolvin D1 Chemical Structure

CAS No. : 872993-05-0

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25 μg (265.6 µM * 250 μL in Ethanol) USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

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Resolvin D1 Related Antibodies

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Description

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Resolvin D1 (RvD1) (1-100 nM; 15 minutes) induces dose-dependent short-term functional changes in primary human macrophages. RvD1 triggers intracellular Ca2+ release, blocks chemotactic migration, and stimulates phagocytosis of microbial particles with maximal efficiency at 10 nM[1]. Resolvin D1 (0-500 nM; 72 hours) shows a strong inhibition of LPS-induced TRAP and cathepsin K expression by RvD1 at different concentrations in RAW264.7 macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Resolvin D1 Related Antibodies
In Vivo

Resolvin D1 (RvD1) (100-1000 ng; i.p.; daily on days 10) improves RA (rheumatoid arthritis) clinical endpoints in arthritic mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-20 g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))[3]
Dosage: 100, 500, and 1000 ng (or 1000 ng, daily on days 4-10)
Administration: i.p. injection; daily on days 10
Result: Exhibit a reduced arthritic score.
Molecular Weight

376.49

Formula

C22H32O5
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(O)=O)O)O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: 99.60%

COA (239 KB)

Handling Instructions (2659 KB)
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Resolvin D1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resolvin D1872993-05-0RvD1Resolvin D 1Resolvin D-1RvD 1RvD-1Endogenous Metabolitepro-resolvingmediatorinflammationacutepolymerizationTNF-αneutrophilapoptoticrheumatoidarthritismacrophagesInhibitorinhibitorinhibit

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